Great news! The CureQ consortium has been granted by the NWO (Dutch Research Council) and started this month. The CureQ program focusses on a distinct group of dominantly inherited neurodegenerative disorders caused by a CAG repeat expansion within the relevant genes, including Huntington’s disease (HD) and various spinocerebellar ataxias (SCA). Over 5.5 million euro will […]
Antisense oligonucleotides as a therapy for Dutch-type Cerebral Amyloid Angiopathy (D-CAA) – New publication
After 4 years of hard work, our paper “Antisense oligonucleotide-induced amyloid precursor protein splicing modulation as a therapeutic approach for Dutch-type cerebral amyloid angiopathy” has been published in Nucleic Acid Therapeutics (DOI: 10.1089/nat.2021.0005). In this study we explored the use of an antisense oligonucleotide (AON) as a therapeutic approach for Dutch-type cerebral amyloid angiopathy (D-CAA), a […]
Tom tells about the new situation
Because of the new coronavirus the LUMC took measures to prevent spreading of the virus. Many people are working from home because of these measures. For me it means that I am working from home as much as I can. Because my mouse experiments take 18 months I am allowed to go to lab. We […]