Neuro-D Lab Leiden

Latest News

  • Antisense oligonucleotides as a therapy for Dutch-type Cerebral Amyloid Angiopathy (D-CAA) – New publication
    After 4 years of hard work, our paper “Antisense oligonucleotide-induced amyloid precursor protein splicing modulation as a therapeutic approach for Dutch-type cerebral amyloid angiopathy” has been published in Nucleic Acid Therapeutics (DOI: 10.1089/nat.2021.0005). In this study we explored the use of an antisense oligonucleotide (AON) as a therapeutic approach for Dutch-type cerebral amyloid angiopathy (D-CAA), a […]
  • New research project on FOXP1 syndrome
    On 1st of June 2021 we started a new research project on FOXP1 syndrome. To do most of the work in this project Elena Daoutsali came back to us, after she left when her PhD period was finished. Good to have her back! Forkhead-box protein P1 (FOXP1) is part of the forkhead-box family of transcription […]
  • Dutch Center for RNA Therapeutics
    On Rare Disease day, 28th of February, last year, Willeke van Roon-Mom, along with others in the LUMC, Radboudumc and Erasmus MC started the Dutch Center for RNA Therapeutics (DCRT). After exactly 1 year, the website www.rnatherapy.nl was launched on which information can be found about DCRT and updates will be posted on things going […]
  • Summary latest advances in delivery of RNA therapies
    Researchers from the NeuroD group in collaboration with other participants from an EU COST Action summarise the latest advances in delivery of RNA therapies. Drugs that target RNA were considered a curiosity until recently, used mainly in research in rare diseases and personalised therapies. However, this new research field has registered a boost in the […]
  • Being a student in COVID-time
    I’m Abel Nijkerk, and I’m a master student Biomedical Sciences at Leiden University. Since February 2020, I’ve been conducting my internship here at the Neuro-D Lab Leiden under David Parfitt‘s supervision. One of the group’s main research lines is the development of an AON for Huntington’s Disease. The group’s been using different models to test […]
  • Going virtual – attending international conferences online
    Written by: Elsa Kuijper “Good morning, good afternoon, good evening to you all!” – that’s how most of the presentations start at an international conference nowadays. Joining the virtual meetings from home at different parts of the world, an early morning meeting for one can be during the night for the other. In the beginning […]
  • Neuro-D Lab Leiden featured in SCAsource spotlight
    The SCAsource website is a website on which information about SCAs and related ataxia diseases is written in easy language by SCA scientists. This way, they want to make this information accessible for ataxia patients and families. Since this year they have a topic in which labs that do research on ataxia diseases can introduce […]
  • Successful Online Dutch HD research symposium
    On Friday November 13, we had a very successful, fully online Dutch HD research symposium November, organized by Harrie Kampinga and Greetje Noppert from the University Medical Center in Groningen. Before lunch we were updated on aggregation propensities of the mutant huntingtin protein by presentations from submitted abstracts from Mark van der Klok (RUG) using […]
  • AFM Telethon fund raising request
    Please support the AFM Telethon fund raising. Each year, the AFM Telethon funds hundreds of researchers, doctoral and post-doctoral students. This year, the Telethon is threatened. Due to the health crisis and the confinement, thousands of events organized by volunteers will not be able to take place. These events represent more than 40% of the […]
  • Brainstorm Teambuilding day
    On wednesday 24th of June, we organised a brainstorm teambuilding day with the whole group. A day to discover what things go well and what things can be better. We rented a nice conference room somewhere in Leiden and discussed our work in several ways. We made use of a test to determine the group […]
  • Boyd tells about the new situation
    The past two months have really been a roller coaster ride. Having all the labs shut down felt very surreal, and not something I accounted for while planning the final year of my PhD. Luckily, I have been allowed to come into the lab every morning to keep long-term studies with iPSCs ongoing, but coming […]
  • Tom tells about the new situation
    Because of the new coronavirus the LUMC took measures to prevent spreading of the virus. Many people are working from home because of these measures. For me it means that I am working from home as much as I can. Because my mouse experiments take 18 months I am allowed to go to lab. We […]
  • Opening Dutch Center for RNA Therapeutics
    The Duchenne Parent Project visited Willeke van Roon-Mom and Annemieke Aartsma-Rus at the LUMC to talk about the Dutch Center for RNA Therapeutics that started in March this year. In the movie you will learn what the purpose of this center is and you can also see how our lab looks!
  • Willeke explains: Impact on our lab
    Willeke tells in this (Dutch) video about the impact that the corona crisis has on our group, since most of us are working from home now. And what to do when we can start up the lab work again?
  • New situation in the lab
    Suddenly there was the new virus that has the whole world in it’s control. In our lab only crucial experiments can continue. Others needed to be stopped for now. Most of our group members are now working from home. For me, Linda, this means sitting behind my laptop where I normally run around in the […]
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