Neuro-D Lab Leiden

Author: Linda

Antisense oligonucleotides as a therapy for Dutch-type Cerebral Amyloid Angiopathy (D-CAA) – New publication

After 4 years of hard work, our paper “Antisense oligonucleotide-induced amyloid precursor protein splicing modulation as a therapeutic approach for Dutch-type cerebral amyloid angiopathy” has been published in Nucleic Acid Therapeutics (DOI: 10.1089/nat.2021.0005). In this study we explored the use of an antisense oligonucleotide (AON) as a therapeutic approach for Dutch-type cerebral amyloid angiopathy (D-CAA), a […]

New research project on FOXP1 syndrome

On 1st of June 2021 we started a new research project on FOXP1 syndrome. To do most of the work in this project Elena Daoutsali came back to us, after she left when her PhD period was finished. Good to have her back! Forkhead-box protein P1 (FOXP1) is part of the forkhead-box family of transcription […]

Dutch Center for RNA Therapeutics

On Rare Disease day, 28th of February, last year, Willeke van Roon-Mom, along with others in the LUMC, Radboudumc and Erasmus MC started the Dutch Center for RNA Therapeutics (DCRT). After exactly 1 year, the website www.rnatherapy.nl was launched on which information can be found about DCRT and updates will be posted on things going […]

Being a student in COVID-time

I’m Abel Nijkerk, and I’m a master student Biomedical Sciences at Leiden University. Since February 2020, I’ve been conducting my internship here at the Neuro-D Lab Leiden under David Parfitt‘s supervision. One of the group’s main research lines is the development of an AON for Huntington’s Disease. The group’s been using different models to test […]

Going virtual – attending international conferences online

Written by: Elsa Kuijper “Good morning, good afternoon, good evening to you all!” – that’s how most of the presentations start at an international conference nowadays. Joining the virtual meetings from home at different parts of the world, an early morning meeting for one can be during the night for the other. In the beginning […]

Successful Online Dutch HD research symposium

On Friday November 13, we had a very successful, fully online Dutch HD research symposium November, organized by Harrie Kampinga and Greetje Noppert from the University Medical Center in Groningen. Before lunch we were updated on aggregation propensities of the mutant huntingtin protein by presentations from submitted abstracts from Mark van der Klok (RUG) using […]

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