Our research paper titled “Amyloid beta (Aβ) accumulations and enhanced forebrain neuronal development and neuronal network formation in cerebral organoids of Dutch-type Cerebral Amyloid Angiopathy patients” was accepted for publication in Frontiers in Aging Neuroscience. Willeke ordered a cake with one of the figures from the paper on it to celebrate with first author Elena, so we had a nice beginning of the year.
In this study we present 3D cerebral organoids of D-CAA patients that exhibit a unique disease landscape compared to control organoids; enhanced neuronal differentiation, Aβ accumulations that is a key feature of D-CAA and TGFβ pathway de-regulation. We used patient-derived iPSC lines where the “Dutch” point mutation proved enough to cause Aβ accumulation. Disease signatures in the TGFβ pathway found by our group on a transcriptomics study of post-mortem D-CAA brain tissue (Grand-Moursel et al. 2017, Grand-Moursel et al. 2017) were also assessed in our organoid model, where a TGFβ pathway signature was found. Finally the increased presence of astrocytes around the Aβ accumulations show the cellular response to the Aβ pathology happening in the cerebral organoid.
The article will be soon available online.